Effect of Detergents on Morphology, Size Distribution, and Concentration of Copolymer-Based Polymersomes

Polymersomes made of amphiphilic diblock copolymers are generally regarded as having higher physical and chemical stability than liposomes composed phospholipids. This enhanced arises from the molecular weight polymer constituents. Despite their increased stability, bilayers solubilized by detergents in a similar manner to lipid bilayers. In this work, we evaluated poly(ethylene glycol)-block-poly(e-caprolactone) (PEG-PCL)-based polymersomes exposed three different detergents: N-octyl-?-d-glucopyranoside (OG), lauryldimethylamine N-oxide (LDAO), Triton X-100 (TX-100). Changes morphology, particle size distribution, concentrations were during titration into polymersome solutions. Furthermore, discussed effect detergent features on solubilization polymeric bilayer compared it results reported literature for polymersomes. information can be used tuning properties PEG-PCL use applications such drug delivery or protein reconstitution studies.